pentobarbital will lessen the level or influence of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Pitolisant publicity is lowered by fifty% if coadministered with potent CYP3A4 inducers.pentobarbital will lessen the extent or influence of erlotinib by impacting hepatic/intestinal enzyme CYP3A